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2D Toolkit

2D Toolkit is packed with features for 2D game development in Unity. The plugin supports many third party formats to integrate into the Unity engine.

16 Alternatives To 2D Toolkit

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Adobe Animate (formerly Flash Professional)

An animation tool that used key frame animation for games and movies.

Creature

Creature 2D Skeletal and Mesh Animation Tool
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Filter Forge

On the surface, Filter Forge is just a Photoshop plugin, a pack of filters that generate textures…
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Grafx2

GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.

Marionette Studio

Marionette Studio is an online animation software for beginners and professionals. Animate 2D characters and environments in minutes with no prior skills.

Moho

Moho is a tool that create animation from start to end, it has a 2D rigging system of the market and mix it with traditional animation tools to make amazing, professional animations.
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RPG Maker VX Ace

Check out all of the amazing features of RPG Maker VX Ace!
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SmoothMoves

SmoothMoves is Unity3D middleware, available on the Asset Store.
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Sprite Something

Sprite Something is an iOS drawing, animation and tilemap application for pixel artists and game developers.