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Adobe Animate (formerly Flash Professional)

An animation tool that used key frame animation for games and movies.

20 Alternatives To Adobe Animate (formerly Flash Professional)

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2D Toolkit

2D Toolkit is packed with features for 2D game development in Unity. The plugin supports many third party formats to integrate into the Unity engine.
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ACDSee

ACDSee is an image viewer that uses very little system resources, and it has a small, sleek size that won’t take up much space on your system.
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Cosmigo Pro Motion NG

Drawing and animation software for Windows designed similar to Amiga Deluxe Paint.

Creature

Creature 2D Skeletal and Mesh Animation Tool
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Grafx2

GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
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Krita

Krita is a professional FREE and open source painting program. It is made by artists that want to seaffordable art tools for everyone. Concept art. texture and matte painters, illustrations and comics.

Marionette Studio

Marionette Studio is an online animation software for beginners and professionals. Animate 2D characters and environments in minutes with no prior skills.

Moho

Moho is a tool that create animation from start to end, it has a 2D rigging system of the market and mix it with traditional animation tools to make amazing, professional animations.

Paintshop Pro

Paintshop Pro is a flexible image-editing software, featuring new creative tools, more precise editing and easy quick fixes for the best photos and designs.
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Pyxel Edit

Welcome! Pyxel Edit is a pixel art editor designed to make it fun and easy to make tilesets, levels and animations. Twitter. Tweets av @PyxelEdit. Share.
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RPG Maker VX Ace

Check out all of the amazing features of RPG Maker VX Ace!
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SmoothMoves

SmoothMoves is Unity3D middleware, available on the Asset Store.