Creature

Creature 2D Skeletal and Mesh Animation Tool

19 Alternatives To Creature

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2D Toolkit

2D Toolkit is packed with features for 2D game development in Unity. The plugin supports many third party formats to integrate into the Unity engine.
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Adobe Animate (formerly Flash Professional)

An animation tool that used key frame animation for games and movies.

AnimeEffects

AnimeEffects is a 2D keyframe animation tool based on deformation of polygon meshes.

App Animations

Gallery of beautiful iOS animations to inspire your next app
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Grafx2

GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
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Live2D Cubism

Live2D is the world’s first drawing technology to enable 3D rendering of 2D images.

Marionette Studio

Marionette Studio is an online animation software for beginners and professionals. Animate 2D characters and environments in minutes with no prior skills.

Moho

Moho is a tool that create animation from start to end, it has a 2D rigging system of the market and mix it with traditional animation tools to make amazing, professional animations.

OpenToonz

OpenToonz is an animation program that is a free software version of Toonz, the animation software…
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SmoothMoves

SmoothMoves is Unity3D middleware, available on the Asset Store.
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Synfig Studio

Just another WordPress site

enve

A new open-source 2D animation software for Linux.