Pylons Framework
Pylons Framework is an open source Web application framework written in Python.
22 Alternatives To Pylons Framework
Adianti Framework
It is an open source tool that provides a complete architecture for developing PHP applications.

Play 2
An open source web framework which follows the model-view-controller architecture. It is light-weight, web-friendly, and stateless. It provides minimal overhead for highly-scalable applications.

Pyramid
Pyramid is an open source web framework written in Python and is based on WSGI.

TurboGears
TurboGears is a web framework to create a database-driven, ready-to-extend application in minutes.
jam-py
Jam.py is an event driven framework for the development of web database applications.