PySimpleGUI

A simple to use GUI that can create custom GUIs

11 Alternatives To PySimpleGUI

Agar

Agar GUI
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Blender

Blender is the open source, cross platform suite of tools for 3D creation.

FLTK

Fast Light Toolkit - Fast Light Toolkit (FLTK)
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GTK

GTK+ is a multi-platform toolkit for creating graphical user interfaces.

JUCE

JUCE is a wide-ranging C++ class library for building rich cross-platform applications and plugins…
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JavaFX

JavaFX is the next step in the evolution of Java as a rich client platform.

Nana C Library

Nana C++ Library - a modern C++ GUI library

PySide

Qt for Python - Qt Wiki

Qt

C++
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Unity

The multiplatform game creation tools for everyone.

wxWidgets

wxWidgets: Cross-Platform GUI Library